W Maruyama Selected Research

salsoline

5/2002	Mitochondria determine the survival and death in apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, and neuroprotection by propargylamines.
1/2001	Enantio-specific induction of apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, in dopaminergic SH-SY5Y cells: suppression of apoptosis by N-(2-heptyl)-N-methylpropargylamine.
1/2000	Neurotoxins induce apoptosis in dopamine neurons: protection by N-propargylamine-1(R)- and (S)-aminoindan, rasagiline and TV1022.
1/2000	Involvement of endogenous N-methyl(R)salsolinol in Parkinson's disease: induction of apoptosis and protection by (-)deprenyl.
1/2000	N-methyl(R)salsolinol and a neutral N-methyltransferase as pathogenic factors in Parkinson's disease.

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W Maruyama Research Topics

Disease

15	Parkinson Disease (Parkinson's Disease) 01/2007 - 01/2000
9	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2007 - 01/2000
8	Neuroblastoma 02/2006 - 01/2000
3	Mitochondrial Diseases (Mitochondrial Disease) 05/2006 - 01/2002
2	Alzheimer Disease (Alzheimer's Disease) 02/2006 - 06/2001
2	Necrosis 01/2001 - 09/2000
2	Parkinsonian Disorders (Parkinsonism) 01/2001 - 01/2000
1	Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular) 03/2011
1	Disease Progression 04/2002
1	Alcoholism (Alcohol Abuse) 04/2000

Drug/Important Bio-Agent (IBA)

6	NeurotoxinsIBA 05/2002 - 01/2000
5	Selegiline (E250)FDA LinkGeneric 01/2007 - 01/2000
5	salsolineIBA 05/2002 - 01/2000
4	rasagiline (Azilect)FDA Link 01/2007 - 07/2000
3	Monoamine Oxidase (MAO)IBA 01/2006 - 04/2002
3	Dopamine (Intropin)FDA LinkGeneric 05/2002 - 01/2000
3	Peroxynitrous Acid (Peroxynitrite)IBA 04/2002 - 01/2001
2	propargylamineIBA 01/2007 - 01/2006
2	Proteasome Endopeptidase Complex (Proteasome)IBA 05/2006 - 10/2004
2	neuromelaninIBA 05/2006 - 01/2006
2	IronIBA 05/2006 - 01/2006
2	Proteins (Proteins, Gene)FDA Link 02/2006 - 01/2002
2	Neuroprotective AgentsIBA 06/2001 - 01/2000
1	Biomarkers (Surrogate Marker)IBA 01/2007
1	alpha-SynucleinIBA 01/2007
1	Amyloid beta-PeptidesIBA 02/2006
1	Amyloid (Amyloid Fibrils)IBA 02/2006
1	UbiquitinIBA 10/2004
1	Pharmaceutical PreparationsIBA 04/2002
1	p38 Mitogen-Activated Protein KinasesIBA 01/2001
1	Messenger RNA (mRNA)IBA 01/2001
1	linsidomineIBA 01/2001
1	3-amino-1-methyl-5H-pyrido(4,3-b)indoleIBA 01/2001
1	gamma-carbolineIBA 01/2001
1	Carbolines (Beta-Carbolines)IBA 01/2001
1	norharmanIBA 01/2001
1	harman (harmane)IBA 01/2001
1	N-nitroso-N-methyltyramine (NNMT)IBA 12/2000
1	IsoquinolinesIBA 09/2000
1	TetrahydropapaverolineIBA 09/2000
1	Adenosine Triphosphate (ATP)IBA 09/2000
1	Neurotransmitter Agents (Neurotransmitter)IBA 04/2000
1	AlkaloidsIBA 04/2000
1	isoquinolineIBA 01/2000
1	salsolinol N-methyltransferaseIBA 01/2000
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2000
1	EnzymesIBA 01/2000
1	MethyltransferasesIBA 01/2000

Therapy/Procedure

1	Transplantation 03/2011
1	Therapeutics 10/2001